Biology of aggression

موضوع: Biology of aggression السبت أبريل 18, 2009 11:45 pm

Biology of aggression

Aggression is directed to and often originates from outside stimuli, but has a very distinct internal character. Using various techniques and experiments, scientists have been able to explore the relationships between various parts of the body and aggression.

Aggression in the brain

Many researchers focus on the brain to explain aggression. The areas involved in aggression in mammals include the amygdala, hypothalamus, prefrontal cortex, cingulate cortex, hippocampus, septal nuclei, and periaqueductal gray of the midbrain. Because of the difficulties in determining the intentions of animals, aggression is defined in neuroscience research as behavior directed at an object or animal which results in damage or harm to that object or animal.
The hypothalamus and periaqueductal gray of the midbrain are the most critical areas controlling aggression in mammals, as shown in studies on cats, rats, and monkeys. These brain areas control the expression of all the behavioral and autonomic components of aggression in these species, including vocalization. They have direct connections with both the brainstem nuclei controlling these functions and areas such as the amygdala and prefrontal cortex.
Electrical stimulation of the hypothalamus causes aggressive behavior^[21] the hypothalamus expresses receptors that help determine aggression levels based on their interactions with the neurotransmitters serotonin and vasopressin.^[22]
The amygdala is also critically involved in aggression. Stimulation of the amygdala results in augmented aggressive behavior in hamsters,^[23]^[24] while lesions of an evolutionarily homologous area in the lizard greatly reduce competitive drive and aggression^[25](Bauman et al 2006). Several experiments in attack-primed Syrian Golden Hamsters support the claim of the amygdala being involved in control of aggression. Using expression of c-fos as a neuroanatomically localized marker of activity, the neural circuitry involved in the state of “attack readiness” in attack primed hamsters was studied. The results showed that certain structures of the amygdala were involved in aggressiveness: the medial nucleus and the cortical nuclei showed distinct differences in involvement as compared to other structures such as the lateral and basolateral nuclei and central nucleus of the amygdala, which were not associated with any substantial changes in aggressiveness. In addition, c-fos expression was found most clearly in the most dorsal and caudal aspects of the corticomedial amygdala (CMA). In the same study, it was also shown that lesions of the CMA significantly reduced the number of aggressive behaviors. Eight of eleven subjects failed to attack. Also a correlation between lesion site and attack latency was determined: the more anterior the lesion, the longer mean elapsed time to the aggressive behavior ^[26].
The prefrontal cortex (PFC) has been implicated in aggressive psychopathology. Reduced activity of the prefrontal cortex, in particular its medial and orbitofrontal portions, has been associated with violent/antisocial aggression. Specifically, regulation of the levels of the neurotransmitter serotonin in the PFC has been connected with a particular type of pathological aggression, induced by subjecting genetically predisposed, aggressive, wild-type mice to repeated winning experience; the male mice selected from aggressive lines had lower serotonin tissue levels in the PFC than the low-aggressive lines in this study ^[27].

clik here
http://en.wikipedia.org/wiki/Aggression#Aggression_and_gender

موضوع: رد: Biology of aggression الأحد أبريل 19, 2009 2:52 pm

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